formulation and in-vitro evaluation of ph-sensitive oil entrapped polymeric blend amoxicillin beads for the eradication of helicobacter pylori
نویسندگان
چکیده
oral ph sensitive drug delivery systems are of utmost importance as these systems deliver the drug at specific part of the gastrointestine (gi) as per the ph of gi, resulting in improved patient therapeutic efficacy and compliance. the ph range of fluids in various segments of the gi tract may provide environmental stimuli for drug release. the aim of this study was to design buoyant beads containing amoxicillin (am) and to evaluate its potential for the eradication of helicobacter pylori (h. pylori). the gel bead of gellan, wherein the oil was entrapped, was blended with hydroxypropyl methyl cellulose or carbopol 934. buoyant beads of gellan were prepared through ionotropic gellation technique to achieve the controlled and ph-sensitive drug release in stomach. the effects of processing variables such as particle size, buoyancy, percent encapsulation efficiency and in-vitro antimicrobial activity were evaluated. thescanning electron micrograph indicated that prepared beads were spherical in shape and all the beads showed satisfactory floating efficiency in the phthalate buffer solution. the diameter of the gel beads was increased through raising the gellan gum and calcium carbonate concentration. the formulation exhibited sustained release profile and was best fitted in the peppas model with n< 0.45. subsequent coating of microbeads exhibited zero-order sustained pattern of the drug release up to 8 h. in-vitro growth inhibition study showed complete eradication of the isolated h. pylori strain .these results provide evidence that the optimized formulation bearing antibiotics like amoxicillin should be useful in h. pylori treatment.
منابع مشابه
Formulation and In-vitro Evaluation of pH-Sensitive Oil Entrapped Polymeric Blend Amoxicillin Beads for the Eradication of Helicobacter pylori
Oral pH sensitive drug delivery systems are of utmost importance as these systems deliver the drug at specific part of the gastrointestine (GI) as per the pH of GI, resulting in improved patient therapeutic efficacy and compliance. The pH range of fluids in various segments of the GI tract may provide environmental stimuli for drug release. The aim of this study was to design buoyant beads c...
متن کاملFormulation and In-vitro Evaluation of pH-Sensitive Oil Entrapped Polymeric Blend Amoxicillin Beads for the Eradication of Helicobacter pylori
Oral pH sensitive drug delivery systems are of utmost importance as these systems deliver the drug at specific part of the gastrointestine (GI) as per the pH of GI, resulting in improved patient therapeutic efficacy and compliance. The pH range of fluids in various segments of the GI tract may provide environmental stimuli for drug release. The aim of this study was to design buoyant beads c...
متن کاملFormulation and In-vitro Evaluation of pH-Sensitive Oil Entrapped Polymeric Blend Amoxicillin Beads for the Eradication of Helicobacter pylori
Oral pH sensitive drug delivery systems are of utmost importance as these systems deliver the drug at specific part of the gastrointestine (GI) as per the pH of GI, resulting in improved patient therapeutic efficacy and compliance. The pH range of fluids in various segments of the GI tract may provide environmental stimuli for drug release. The aim of this study was to design buoyant beads cont...
متن کاملFormulation and In-vitro evaluation of pH sensitive oil entrapped buoyant beads of amoxicillin
A gastro retentive pH sensitive system has been a frontier approach to release the drug in controlled manner in stomach and duodenum. The aim of the study is to develop reliable formulation of amoxicillin which will release the drug in controlled way at specific site with acidic pH stimulus present in the gastric region. In the present investigation pectin based oil entrapped micro gel beads we...
متن کاملHelicobacter pylori and Migraine: Is Eradication of Helicobacter pylori Effective in Relief of Migraine Headache?
Background: Association between Helicobacter pylori (HP) infection and migraine and the effect of HP eradication on relief of migraine headache have been studied but the results are controversial. Objectives: To evaluate the effect of HP eradication in treatment of patients affected by migraine. Materials and Methods: Eighty consecutive HP infected patients affected by migraine without au...
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عنوان ژورنال:
the iranian journal of pharmaceutical researchجلد ۱۱، شماره ۲، صفحات ۴۴۷-۴۵۵
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